This is not consistent with our long-standing experience. Something often put forth is that DIM is hard to absorb. the concentrations of the substance (called I3C) that converts to DIM in the body can vary, as can conversion rates in the individual. The only problem with the latter choice is inconsistency, i.e. Yet, with little to no side-effects and high efficacy you don't need to wait for the drug to simply take a DIM supplement, or eat lots of cruciferous vegetables it's derived from. The answer of course is that there are intense efforts being made to create a drug from DIM. ![]() Given estimates that 60% of men over 60 already have some prostate cancer, this is big news! In fact, if men and women knew how much evidence there was for DIM preventing and treating both breast and prostate cancer, the obvious question becomes "Why aren't we hearing about this in the media, or from our doctor?" (After all, if these effects were achieved by a pharmaceutical they would be trumpeted as front page news across the globe.) The selective effects of DIM in reducing androgen-receptor concentration, and hence activity, in the prostate gland mean that cells are less likely to grow and divide, potentially inhibiting the development of both cancerous, and hyperplastic changes present in simple prostatic enlargement, (i.e. Further, in the brief treatment period PSA (Prostate Specific Antigen) levels dropped in 71% of subjects. Yet, even more important was the fact that, whereas before treatment, nuclear androgen receptors were present in all the prostate samples, after treatment, 96% of the prostates had NO nuclear androgenic (testosterone) receptor complexes. ![]() Note that this level was present in the men evaluated at two weeks, and prostatic levels of DIM did not continue to increase with time. Yet, of great significance was the fact that prostate DIM concentrations (in 26/28 subjects) averaged 14.2 ng/ml, indicating that DIM was selectively concentrated in the prostate gland. The men's blood levels of DIM markedly increased, going from being undetectable to an average of 9 ng/ml. DIM blood levels were evaluated again prior to scheduled surgical removal of the mens' prostates, times ranging from 14-72 days. After measuring the subject's blood levels of DIM, and determining androgen receptor concentrations in their prostates through biopsy, the men were then given 225 mg of DIM twice a day. The study examined the effects of DIM (3, 3'-diindolylmethane - an extract from cruciferous vegetables), on the number and activity of testosterone (androgen) receptors present on prostate cells in 28 men with prostate cancer. ![]() A recent study indicates DIM is also extremely useful for inhibiting the proliferative (growth promoting) effects of testosterone on prostate cells, and may help reduce the need for anti-testosterone treatment in men with prostate cancer. As we at Optimum Health have advised since 2002 when we first identified and incorporated a high quality Diindolylmethane (DIM) into our supplement line, it isn't only beneficial for improving women's hormonal status. Good news for men suffering with prostate difficulties.
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